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Welcome to the Warner Lab

Embryology,
Marine Biotechnology

Learn more

About

The Warner Lab is part of the Biology and Marine Biology Department at UNC Wilmington. We are located at the UNCW Center for Marine Science. - We use marine invertebrates to study how organisms grow and develop, and how we can leverage biological innovations into new technologies.

Research

Gene Networks of Development

Gene Networks of Development
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Marine Biotechnology

Marine Biotechnology
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People

We are currently recruiting at all levels. For more information please send an email to warnerj \at/ uncw.edu

Links

Web apps:

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NvERTx

A web tool for exploring gene expression during regeneration and embryogenesis

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The virtual embryo

A 3D model and gene expression database of the Nematostella embryo

Other stuff:

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Pokemodels!

An educational outreach initiative.

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2-BitBio.com

A blog of bioinformatics tutorials

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github.com/ScientistJake

All of my code!

Publications

Vyas H, Schrankel CS, Espinoza JA, Mitchell KL, Nesbit KT, Jackson E, Chang N, Lee Y, Warner J, Reitzel A, Lyons DC, Hamdoun A. Generation of a homozygous mutant drug transporter (ABCB1) knockout line in the sea urchin Lytechinus pictus. Development. 2022 Jun 1;149(11):dev200644. doi: 10.1242/dev.200644. Epub 2022 Jun 6. PMID: 35666622. PubMed.

Desplat Y, Warner JF, Lopez JV. Transcriptome Sequences from the Tropical Marine Sponge Cinachyrella alloclada. J Hered. 2021 Dec 7:esab075. doi: 10.1093/jhered/esab075. Epub ahead of print. PMID: 34875073. PubMed.

McClay DR, Croce JC, Warner JF. Conditional specification of endomesoderm. Cells Dev. 2021 Jul 7:203716. doi: 10.1016/j.cdev.2021.203716. PMID: 34245941. PubMed.

Warner JF, Lord JW, Schreiter SA, Nesbit KT, Hamdoun A, Lyons DC. Chromosomal-level genome assembly of the painted sea urchin Lytechinus pictus, a genetically enabled model system for cell biology and embryonic development. Genome Biol Evol. 2021 Mar 26:evab061. doi: 10.1093/gbe/evab061. PMID: 33769486. PubMed.

Warner JF, Rottinger E. (2021) Transcriptomic Analysis in the Sea Anemone Nematostella vectensis. Methods Mol Biol. 2021;2219:231-240. doi: 10.1007/978-1-0716-0974-3_14. PMID: 33074544 PubMed.

McClay DR, Warner J, Martik M, Miranda E, Slota L. (2020) Gastrulation in the sea urchin. Current Topics in Developmental Biology. Development. 2020 ;136:195-218. DOI: 10.1016/bs.ctdb.2019.08.004.PubMed.

Warner JF, Guerlais V, Amiel AR, Honston H, Nedoncelle K, Rottinger ER (2018) NvERTx: A gene expression database to compare Embryogenesis and Regeneration in the sea anemone Nematostella vectensis. Development. 2018 May 17;145(10). PubMed.

Warner JF, Miranda EL, McClay DR (2016) Contribution of hedgehog signaling to the establishment of left-right asymmetry in the sea urchin. Developmental Biology 411(2):314-24. PubMed.

Amiel AR, Johnston HT, Nedoncelle K, Warner JF, Ferreira S, Röttinger E (2015) Characterization of Morphological and Cellular Events Underlying Oral Regeneration in the Sea Anemone, Nematostella vectensis. International Journal of Molecular Sciences 16(12):28449-71. PubMed.

Warner JF, McClay DR (2014) Left-right asymmetry in the sea urchin. Genesis 52(6):481-487. Genesis.

Warner JF, McCarthy AM, Morris RL, McClay DR (2014) Hedgehog signaling requires motile cilia in the sea urchin. Molecular Biology and Evolution 31(1):18-22. PubMed.

Warner JF, McClay DR (2014) Perturbations to the hedgehog pathway in sea urchin embryos. Methods in Molecular Biology 1128:211-21. PubMed.

Warner JF, Lyons DC, McClay DR (2012) Left-right asymmetry in the sea urchin embryo: BMP and the asymmetrical origins of the adult. Plos Biology 10(10):e1001404. PubMed.

Walton KD, Warner JF, Hertzler PH, McClay DR (2009) Hedgehog signaling patterns mesoderm in the sea urchin. Developmental Biology 331(1):26-37. PubMed.

Gene Networks of Development

Gastrulation, the processes by which our embryonic tissue layers physically segregate via coordinated cell movements, is a critical event during embryogenesis. Gastrulation, like many other events during embryogenesis, is coordinated by a regulatory cascade of genetic interactions that we term gene regulatory networks (GRN). In the lab, we use molecular approaches, including CRISPR, live imaging, and embryo manipulation, to develop GRN models and connect them to downstream morphological processes. We do this work primarily in two complementary model systems: the sea urchin Lytechinus variegatus and the sea anemone Nematostella vectensis.

Marine Biotechnology

Cnidarians, a group of organisms that includes corals, sea anemones, and jellyfish exhibit an extraordinary suite of biological innovations. Cnidarians can regenerate, they make some of the most potent venoms in the animal kingdom, and some are thought to be immortal. The keys to these innovations are encoded in their genomes. In the lab we are using bioinformatic and comparative genomic approaches to identify and investigate previously unknown cnidarian genes for potential biotechnological and biomedical applications.